Hydrochloric Acid → HCID 23284712, compound

HRID 369291Notes

Reaction equation

HRID 369291 reaction equation
Cl.[NH2:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7](=[O:35])[C:8]([C:30]([O:32]CC)=[O:31])=[CH:9][N:10]2[C:14]2[CH:19]=[C:18]([NH:20]C(OC(C)(C)C)=O)[C:17]([F:28])=[CH:16][C:15]=2[F:29])=[CH:5][C:4]=1[O:36][CH3:37]>>[NH2:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7](=[O:35])[C:8]([C:30]([OH:32])=[O:31])=[CH:9][N:10]2[C:14]2[CH:19]=[C:18]([NH2:20])[C:17]([F:28])=[CH:16][C:15]=2[F:29])=[CH:5][C:4]=1[O:36][CH3:37]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 23284680HCID 23284680, compound

Product 1

HCID 23284712HCID 23284712, compound

Procedure

12N Hydrochloric acid (2 ml) was added to ethyl 7-amino-1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-6-methoxy-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate, and the mixture was heated under reflux for 3 hours. After the reaction mixture was allowed to cool, solids deposited were collected by filtration, washed successively with water and ethanol and then dried to obtain the title compound (52 mg) as a yellow powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. temperatureto cool
  4. filtrationsolids deposited were collected by filtration
  5. washwashed successively with water and ethanol
  6. customdried

Sources & evidence

ORD record
ord-14a9fc7c4feb45d3a3df4b04003e7ad9
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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