反应详情

温度

65 °C

To a 50 gallon glass lined reactor was added 23.07 pounds (0.769 mole--1.04 equiv.) of paraformaldehyde, followed by 92 pounds (%Wt/Wt Phenol to Solvent--100%) of acetonitrile, and then 92 pounds (0.739 mole--1.0 equiv.) of 98.0% pure m-ethylphenol. The mixture was heated to 65° C., and 66.2 pounds (0.761 mole--1.03 equiv.) of morpholine was added at a rate of 0.5 lb./min. during a two hour period. Upon completion of addition, the reaction mixture was heated to 65-70° C. where it stirred for three hours. After this time, the reaction mixture was concentrated under vacuum at 70° C., yielding 171 pounds of 89.4% pure 2-(morpholin4-ylmethyl)-5-ethylphenol (93% yield).

1. additionUpon completion of addition
2. temperaturethe reaction mixture was heated to 65-70° C. where it
3. concentrationAfter this time, the reaction mixture was concentrated under vacuum at 70° C.