Ethyl Acrylate → Ethyl 3-(2-ethoxycarbonylethyl)amino-2,2-dimethylbutanoate

HRID 369459Notes

Reaction equation

HRID 369459 reaction equation
[NH2:1][CH:2]([CH3:11])[C:3]([CH3:10])([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:12]([O:16][CH2:17][CH3:18])(=[O:15])[CH:13]=[CH2:14]>>[CH2:17]([O:16][C:12]([CH2:13][CH2:14][NH:1][CH:2]([CH3:11])[C:3]([CH3:9])([CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[O:15])[CH3:18]

Participants

3

Reactant 2

HCID 8821Ethyl AcrylateHCID 23283845Ethyl 3-amino-2,2-dimethylbutanoate

Product 1

HCID 23283843Ethyl 3-(2-ethoxycarbonylethyl)amino-2,2-dimethylbutanoate

Procedure

In the second stage of the reaction, the ethyl 3-amino-2,2-dimethylbutanoate derivative 4 is reacted with ethyl acrylate to obtain the corresponding ethyl 3-(2-ethoxycarbonylethyl)amino-2,2-dimethylbutanoate derivative 5--which in the case of the preparation of BIII 277 might be, for example: ethyl 3-(2-ethoxycarbonylethyl)amino-4-(3-methoxyphenyl)-2,2-dimethylbutanoate (R2 =CH3O): ##STR4##

Workup

  1. customIn the second stage of the reaction

Sources & evidence

ORD record
ord-092cb85e747445b1811dd473085e4bf4
Source dataset
uspto-grants-2000_10
Patent number
US06136980

Reaction notes

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