Ammonia → HCID 22714980, compound

HRID 369463Notes

Reaction equation

HRID 369463 reaction equation
N#[C-].C(N(CC)CC)C.Cl[SiH](Cl)Cl.C(Cl)Cl.[F:17][C:18]1[C:19]([Si:27]([CH3:30])([CH3:29])[CH3:28])=[C:20]([N:24]=[C:25]=O)[CH:21]=[CH:22][CH:23]=1.N>>[F:17][C:18]1[C:19]([Si:27]([CH3:30])([CH3:29])[CH3:28])=[C:20]([N+:24]#[C-:25])[CH:21]=[CH:22][CH:23]=1

Participants

7

Reactant 6

HCID 222AmmoniaHCID 5975CyanideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 24811TrichlorosilaneHCID 22714985HCID 22714985, compound

Product 1

HCID 22714980HCID 22714980, compound

Procedure

A deoxygenation then afforded the expected isonitrile. See Baldwin, J. E. et al., Tetrahedron , 39, 2989 (1983). Triethylamine (4.10 mL, 29.3 mmol) was added slowly at 0° C. to a 2 N solution of trichlorosilane in CH2Cl2 (8.40 mL, 16.8 mmol) followed, 5 min latter, by the compound prepared in Example (3) (2.35 g. 11.2 mmol). After 1 h 30 at 0° C. and 30 min at room temperature, the solution was saturated with NH3, filtered over Celite, washed with 5% NaH2PO4 and dried (Na2SO4). The crude obtained after evaporation of the solvent was then subjected to flash-chromatography (hexanes/AcOEt 95:5) to afford 1.42 g (66%) of a slightly purple liquid: IR (neat, cm-1) 2114, 1598, 1440, 1254, 1237, 1110, 943, 848, 793; 1H NMR (300 MHz, CDCl3) δ0.45 (d, J=1.8 Hz, 9H), 7.01 (br t, J=8.3 Hz, 1H), 7.17 (br d, J=7.7 Hz, 1H), 7.32 (ddd, J1 =J2 =8.0 Hz, J3 =6.1 Hz, 1H); 13C NMR (75 MHz, CDCl3) δ0.1, 116.5 (d, JCF =26 Hz), 124.3, 131.6, 166.8 (d, JCF =243 Hz), 166.9; HRMS (EI) m/z calcd for C10H12FNSi (M+) 193.0723, found 193.0715; LRMS (EI) m/z 193 (M+), 178, 150, 116, 105.

Workup

  1. waitAfter 1 h 30 at 0° C.
  2. custom30 min
  3. customat room temperature
  4. filtrationfiltered over Celite
  5. washwashed with 5% NaH2PO4
  6. dry with materialdried (Na2SO4)
  7. customThe crude obtained
  8. customafter evaporation of the solvent
  9. customto afford 1.42 g (66%) of a slightly purple liquid

Sources & evidence

ORD record
ord-950b250e789447cbb130c4d75c4c4be8
Source dataset
uspto-grants-2000_10
Patent number
US06136978

Reaction notes

Loading…