Tetrahydrofuran → HCID 178425916, compound

Temperature

-70 °C

A 2.5M solution of butyllithium in hexane (4.5 mL, 11 mmol) was added dropwise with stirring to a solution of 1.00 mL (10.2 mmol) of 1,2-difluorobenzene in 10 mL of dry tetrahydrofuran cooled to -70° C. under a nitrogen atmosphere. After 10 min, 0.80 mL (11 mmol) of dimethyl disulfide was added dropwise with stirring. Another 11 mmol of 2.5M butyllithium was then added and, after 10 min, the reaction mixture was quenched by bubbling a stream of dry carbon dioxide into the solution. The resulting mixture was diluted with water and the mixture was washed with ether and then acidified with 1N aqueous hydrochloric acid. The resulting heavy white precipitate was recrystallized from a mixture of ethyl acetate and heptane to obtain 0.65 g (31 percent of theory) of the title compound as a white solid melting at 214-215° C.

1. customthe reaction mixture was quenched
2. customby bubbling a stream of dry carbon dioxide into the solution
3. additionThe resulting mixture was diluted with water
4. washthe mixture was washed with ether
5. customThe resulting heavy white precipitate was recrystallized from a mixture of ethyl acetate and heptane

ORD record

ord-4b85fa5653b64c3586802b983b37fa9d

Source dataset

uspto-grants-2000_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06140271