反应详情

To a mixture of 16.0 g of 4-(2,2-diethoxyethoxy)butanol, 18.9 g of 2,6-diethyl-4-benzoyloxyphenol, 20.2 g of triphenylphosphine and 200 ml of tetrahydrofuran was slowly added dropwise 17.0 g of dilsopropyl azodicarboxylate with stirring under ice cooling. After stirring at room temperature for 6 hours, the reaction mixture was concentrated. The residue was subjected to silica gel chromatography, which afforded 31.4 g of 3,5-diethyl-1-benzoyloxy-4-(4-(2,2-diethoxyethoxy)butyloxy)benzene (yield, 88%), nD24.8 1.5129.

1. stirringAfter stirring at room temperature for 6 hours
2. concentrationthe reaction mixture was concentrated