Indoline → 4-(2,3-Dihydroindol-1-yl)-6-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine

HRID 369716Notes

Reaction equation

HRID 369716 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20]1>>[N:19]1([C:2]2[C:3]3[CH:10]=[C:9]([C:11]4[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=4)[NH:8][C:4]=3[N:5]=[CH:6][N:7]=2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 10328IndolineHCID 232824574-Chloro-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 232824664-(2,3-Dihydroindol-1-yl)-6-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine

Procedure

This product is prepared in a manner analogous to that described in Example 1 from 4-chloro-6-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine and 2,3-dihydroindole (1.1 equivalents). M.p. >300° C.; FAB-MS: (M+H)+ =343 (corresponds to C21H18N4O).

Workup

  1. customThis product is prepared in a manner analogous to

Sources & evidence

ORD record
ord-cea43a8abcb1415bbbf2ce58c997d3f3
Source dataset
uspto-grants-2000_10
Patent number
US06140317

Reaction notes

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