Formic Acid → HCID 178518052, compound

HRID 369840Notes

Reaction equation

HRID 369840 reaction equation
[NH2:1][C:2]1[NH:3][C:4]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)=[CH:5][C:6]=1[C:7]([O:9]CC)=O.[CH3:24][N:25](C=O)C.C(O)=O>C(N)=O.C(O)(C)C>[C:12]1([C:4]2[NH:3][C:2]3[N:1]=[CH:24][N:25]=[C:7]([OH:9])[C:6]=3[CH:5]=2)[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:14][CH:13]=1

Participants

6

Reactant 3

HCID 284Formic AcidHCID 6228DimethylformamideHCID 857173022-Amino-3-ethoxycarbonyl-5-(biphen-4-yl)-1H-pyrrole

Product 1

HCID 178518052HCID 178518052, compound

Reagents, catalysts & solvents 2

HCID 713FormamideSolventHCID 3776IsopropanolSolvent

Procedure

766 mg (2.5 mmol) of 2-amino-3-ethoxycarbonyl-5-(biphen-4-yl)-1H-pyrrole are stirred in 5 ml of formamide, 2.5 ml of DMF and 1.25 ml of formic acid for 20 h at 150° C. The reaction mixture is diluted with isopropanol and filtered. Washing with isopropanol and hexane yields the title compound; m.p.>300° C.; FAB-MS: (M+H)+ =288.

Workup

  1. filtrationfiltered
  2. washWashing with isopropanol and hexane

Sources & evidence

ORD record
ord-dc62a597c27d4486acf47fc1829cebd0
Source dataset
uspto-grants-2000_10
Patent number
US06140332

Reaction notes

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