反应详情

Under a protective gas, 430.5 mg (1.5 mmol) of 6-(biphen-4-yl)-7H-pyrrolo[2,3-d]-pyrimidin-4-ol in 6 ml of phosphorus oxychloride are heated at boiling for 4 hours. The reaction mixture is poured into ice-water and ethyl acetate. The aqueous phase is separated off and extracted with ethyl acetate. Concentrating the organic phases by evaporation and stirring the residue in hot THF/isopropanol yield the title compound; m.p. 295-300° C. (decomposition); FAB-MS: (M+H)+ =306.

1. customThe aqueous phase is separated off
2. extractionextracted with ethyl acetate
3. concentrationConcentrating the organic phases
4. customby evaporation