Formamide → HCID 178488432, compound

HRID 369852Notes

Reaction equation

HRID 369852 reaction equation
[NH2:1][C:2]1[NH:3][C:4]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)=[CH:5][C:6]=1[C:7](OCC)=[O:8].[CH:20]([NH2:22])=O>CN(C=O)C.C(O)=O>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([C:4]2[NH:3][C:2]3[N:1]=[CH:20][N:22]=[C:7]([OH:8])[C:6]=3[CH:5]=2)=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 713FormamideHCID 23282706Ethyl 2-amino-5-(4-methoxyphenyl)-1H-pyrrole-3-carboxylate

Product 1

HCID 178488432HCID 178488432, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 6228DimethylformamideSolvent

Procedure

Under a protective gas, 611 mg (2.3 mmol) of 2-amino-3-ethoxycarbonyl-5-(4-methoxy-phenyl)-1H-pyrrole in 5 ml of formamide, 2.5 ml of DMF and 1.25 ml of formic acid are heated at 150° C. overnight. Working-up analogously to Step 8.2 yields the title compound; m.p.>300° C.; FAB-MS: (M+H)+ =242.

Sources & evidence

ORD record
ord-acc756ec38284bed99b573c3fd42a420
Source dataset
uspto-grants-2000_10
Patent number
US06140332

Reaction notes

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