反应详情

2.5 g (97 mmol) of 2-amino-3-ethoxycarbonyl-5-(4-nitro-phenyl)-pyrrole, 19.4 ml of formamide, 9.7 ml of DMF and 3.1 ml of formic acid are stirred together at 150° C. for 22 hours. 1 ml of isopropanol is added to the hot reaction mixture. The reaction mixture is cooled and the product that has precipitated is filtered off. The product is washed in succession three times with 10 ml of ethanol each time, twice with 10 ml of isopropanol each time and twice with 10 ml of hexane each time, yielding the title compound in the form of rust-brown crystals which are used for the next step; MS: (M)+ =256.

1. temperatureThe reaction mixture is cooled
2. customthe product that has precipitated
3. filtrationis filtered off
4. washThe product is washed in succession three times with 10 ml of ethanol each time