Ammonium Hydroxide → HCID 70043658, compound

HRID 37007Notes

Reaction equation

HRID 37007 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[N+:28]([O-:30])=[O:29])[C:7](/[CH:10]=[C:11](\[CH2:15][C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)/[C:12]([OH:14])=O)=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].S(Cl)(Cl)=O.[OH-].[NH4+:36]>>[CH2:1]([C:5]1[N:6]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[N+:28]([O-:30])=[O:29])[C:7](/[CH:10]=[C:11](\[CH2:15][C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)/[C:12]([NH2:36])=[O:14])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 14923Ammonium HydroxideHCID 24386Thionyl ChlorideHCID 149529063-[2-Butyl-3-(2-nitro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid

Product 1

HCID 70043658HCID 70043658, compound

Procedure

(E)-3-[2-n-Butyl-1-{(2-nitrophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid, prepared in Example 55, was treated with thionyl chloride and then ammonium hydroxide, as described in Example 54, to give the title compound; mp 183°-185° C.

Sources & evidence

ORD record
ord-6a9b101bc495456d85ceb61efbcd487e
Source dataset
uspto-grants-1995_05
Patent number
US05418250

Reaction notes

Loading…