反应详情

温度

0 °C

Hydroquinone (440 g) was dissolved in a solution of sodium hydroxide (160 g) in water (1600 ml) and to the resulting solution was added dropwise a solution of acetyl chloride (346 g) in tetrahydrofuran (346 g), while maintaining the temperature at 0° C. with ice-cooling. After addition, the mixture was stirred at 0° C. for 1 hour and then at room temperature for 2 hours. The reaction mixture was extracted with ethyl acetate. The ethyl acetate extract was washed with a small amount of water. Ethyl acetate was removed and the residue was distilled under a reduced pressure to give hydroquinone monoacetate (188 g). b.p. 144°-147° C./4 mmHg.

1. temperaturecooling
2. additionAfter addition
3. waitat room temperature for 2 hours
4. extractionThe reaction mixture was extracted with ethyl acetate
5. extractionThe ethyl acetate extract
6. washwas washed with a small amount of water
7. customEthyl acetate was removed
8. distillationthe residue was distilled under a reduced pressure