Dabco → HCID 13645939, compound

HRID 370616Notes

Reaction equation

HRID 370616 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14]([N:17]=[C:18]=[O:19])(=[O:16])=[O:15])(=[O:7])=[O:6].[NH2:20][C:21]1[N:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[N:22]=1.C1N2CCN(CC2)C1>ClCCl>[CH3:30][O:29][C:23]1[CH:24]=[C:25]([O:27][CH3:28])[N:26]=[C:21]([NH:20][C:18]([NH:17][S:14]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[S:5]([CH2:4][CH2:3][O:2][CH3:1])(=[O:7])=[O:6])(=[O:15])=[O:16])=[O:19])[N:22]=1

Participants

5

Reactant 3

HCID 9237DabcoHCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 13645938HCID 13645938, compound

Product 1

HCID 13645939HCID 13645939, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2-[(2-methoxyethyl)sulfonyl]benzenesulfonyl isocyanate (1.7 g, 0.0057 mol) in dichloromethane (10 ml) was added to 2-amino-4,6-dimethoxypyrimidine (0.70 g, 0.0045 mol) and DABCO (catalytic amount); the mixture was stirred at room temperature under nitrogen overnight. Filtration gave N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-[(2-methoxyethyl)sulfonyl]benzenesulfonamide (1.43 g) as a white powder, m.p. 187°-192°.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-82358303f68749a0935b44a1a0a4f180
Source dataset
uspto-grants-1985_07
Patent number
US04528024

Reaction notes

Loading…