HCID 86740187, compound → 4-amino-5-fluoropent-2-enoic acid

HRID 370633Notes

Reaction equation

HRID 370633 reaction equation
Cl.[NH2:2][C@H:3]([CH2:10][F:11])/[CH:4]=[CH:5]/[C:6]([O:8]C)=[O:7]>Cl>[NH2:2][C@H:3]([CH2:10][F:11])/[CH:4]=[CH:5]/[C:6]([OH:8])=[O:7]

Participants

3

Reactant 1

HCID 86740187HCID 86740187, compound

Product 1

HCID 64388034-amino-5-fluoropent-2-enoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

410 mg of 26C was stirred in 25 ml of 5N hydrochloric acid for 48 hours at room temperature, then the solvent was evaporated at a temperature below 40° C. and the residue was dried over phosphorus pentoxide for 24 hours. The resulting product was recrystallized from acetic acid/ethyl acetate to give 26, as powdery white flakes, m.p.: 169°-170° C.

Workup

  1. customthe solvent was evaporated at a temperature below 40° C.
  2. dry with materialthe residue was dried over phosphorus pentoxide for 24 hours
  3. customThe resulting product was recrystallized from acetic acid/ethyl acetate

Sources & evidence

ORD record
ord-1a9a62e4711a48a5bcd47a484bfbee79
Source dataset
uspto-grants-1985_07
Patent number
US04528028

Reaction notes

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