Potassium Carbonate → HCID 2817949, compound

HRID 371036Notes

Reaction equation

HRID 371036 reaction equation
[Cl:1][C:2]1[C:3]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.C([O-])([O-])=O.[K+].[K+].Br[CH:24]([CH3:29])[C:25]([O:27][CH3:28])=[O:26]>CC(C)=O>[Cl:1][C:2]1[C:3]([O:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH:24]([CH3:29])[C:25]([O:27][CH3:28])=[O:26])=[CH:12][CH:11]=2)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 95576Methyl 2-bromopropionateHCID 6208804-(3,5-Dichloro-pyridin-2-yloxy)-phenol

Product 1

HCID 2817949HCID 2817949, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The above phenol (1.3 g, 5.08 mm), K2CO3 (1.05 g), methyl α-bromopropionate (0.85 ml, 1.5 eq) and acetone (20 ml) is refluxed for 8 hours. The mixture is then filtered and the filtrate concentrated to give oily methyl 2-[4-(3,5-dichloro-2-pyridyloxy)phenoxy]propionate.

Workup

  1. filtrationThe mixture is then filtered
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-412c945b397b4104bc2ae1227d175687
Source dataset
uspto-grants-1985_07
Patent number
US04529438

Reaction notes

Loading…