Hydrochloric Acid → HCID 20274098, compound

HRID 371047Notes

Reaction equation

HRID 371047 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5](Cl)=[O:6].Cl.[FH:17]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5]([F:17])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 14917Hydrofluoric AcidHCID 181858383-Bromo-4-(trifluoromethoxy)benzoyl chloride

Product 1

HCID 20274098HCID 20274098, compoundYield 88.7%

Procedure

100 ml of anhydrous hydrofluoric acid were cooled to -10° C. 420 g of 3-bromo-4-trifluoromethoxy-benzoyl chloride were added dropwise in the course of two hours at -5° to 0° C., with vigorous evolution of hydrogen chloride. After the evolution of hydrogen chloride had ceased, the temperature was allowed to increase and the reaction allowed to go to completion at 20° C. The excess hydrofluoric acid was distilled off. The residue was purified by distillation. 352.8 g (88.7% of theory) of 3-bromo-4-trifluoromethoxybenzoyl fluoride of refractive index nD20 : 1.4760 were obtained. ##STR21##

Workup

  1. temperatureto increase
  2. customto go to completion at 20° C
  3. distillationThe excess hydrofluoric acid was distilled off
  4. distillationThe residue was purified by distillation

Sources & evidence

ORD record
ord-28ba23e51dad4ed68e2f2a9e0fe920b9
Source dataset
uspto-grants-1985_07
Patent number
US04529557

Reaction notes

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