反应详情

温度

100 °C

In 6 ml of ethanol was suspended 0.50 g of 2-(7-acetamido-3,4-dihydro-2,2-dimethyl-6-nitro-2H-1,4-benzoxazin-4-yl)pyridine-N-oxide followed by addition of 6 ml of 5 N hydrochloric acid, and the mixture was stirred at 100° C. for 2 hours. The reaction mixture was poured into ice-water, neutralized with excess sodium hydrogen carbonate, and extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and the solvent was distilled off. The-resulting residue was recrystallized from ethanol to give 359 mg of 2-(7-amino-3,4-dihydro-2,2-dimethyl-6-nitro-2H-1,4-benzoxazin-4-yl)pyridine N-oxide.

1. extractionextracted with chloroform
2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
3. distillationthe solvent was distilled off
4. customThe-resulting residue was recrystallized from ethanol