反应详情

温度

60 °C

To a mixture of 2-(chloromethyl)quinoline hydrochloride (1 g, 4.6 mmol) and methyl p-hydroxyphenylacetate (0.83 g, 5 mmol) in anhydrous dimethylformamide (20 mL), was added potassium carbonate (2.33 g) and the mixture was heated at 60° C. for 8 h. Dimethylformamide was removed, and the residue was partitioned between water and chloroform. The organic phase was dried over sodium sulfate and the solvent was removed, to afford 1.68 g of a crude product that was purified by chromatography on silica gel (ethyl acetatehexane 1:1), to give 1.2 g of the title compound (yield: 84%).

1. customDimethylformamide was removed
2. customthe residue was partitioned between water and chloroform
3. dry with materialThe organic phase was dried over sodium sulfate
4. customthe solvent was removed
5. customto afford 1.68 g of a crude product that
6. customwas purified by chromatography on silica gel (ethyl acetatehexane 1:1)