Chlorotrimethylsilane → HCID 70401955, compound

HRID 371316Notes

Reaction equation

HRID 371316 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([Si:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([OH:15])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:4][CH:3]=1.Cl[Si:24]([CH3:27])([CH3:26])[CH3:25].C(N(CC)CC)C>O1CCCC1>[F:22][C:19]1[CH:20]=[CH:21][C:16]([Si:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)([O:15][Si:24]([CH3:27])([CH3:26])[CH3:25])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 8471TriethylamineHCID 13392470HCID 13392470, compound

Product 1

HCID 70401955HCID 70401955, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of 1.5 g (0.0047 mol) of bis(4-fluorophenyl)hydroxy(1H-imidazol-1-ylmethyl)silane in 20 ml of tetrahydrofuran was added 0.8 ml (0.0063 mol) of chlorotrimethylsilane. A solution of 0.8 ml (0.0057 mol) of triethylamine in 5 ml of tetrahydrofuran is added dropwise, giving a thick white precipitate. The mixture is stirred overnight at room temperature, then filtered and concentrated to an oil. The residue is taken up in ether, filtered, and the filtrate is evaporated to afford the title compound.

Workup

  1. customgiving a thick white precipitate
  2. filtrationfiltered
  3. concentrationconcentrated to an oil
  4. filtrationfiltered
  5. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-6be7002fc3cc42598c03426ee83e9b45
Source dataset
uspto-grants-1985_07
Patent number
US04530922

Reaction notes

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