Hydrochloric Acid → HCID 53911695, compound

HRID 371346Notes

Reaction equation

HRID 371346 reaction equation
CC(C)([O-])C.[K+].Cl[C:8]([S:13][CH2:14][CH2:15][CH2:16][NH:17][C:18](=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH:9][N+:10]([O-:12])=[O:11].Cl.[Cl-].[Na+]>C(O)(C)(C)C>[C:18]([N:17]1[CH2:16][CH2:15][CH2:14][S:13][C:8]1=[CH:9][N+:10]([O-:12])=[O:11])(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 23665647Potassium tert-butoxideHCID 53987945HCID 53987945, compound

Product 1

HCID 53911695HCID 53911695, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent2×

Procedure

A solution of 0.10 g of potassium t-butoxide in 3 ml of t-butanol was added drop-by-drop over 5 minutes to a solution of 0.23 g of 15 in 10 ml of t-butanol under nitrogen, at room temperature. After 40 minutes, the mixture was poured into 2% hydrochloric acid saturated with sodium chloride and the resulting mixture was extracted with methylene chloride. The solvent was purified over silica gel to give 24, as a solid, m.p.: 90°-92° C.

Workup

  1. extractionthe resulting mixture was extracted with methylene chloride
  2. customThe solvent was purified over silica gel

Sources & evidence

ORD record
ord-ebea0591aa744d988701e3565d11a82f
Source dataset
uspto-grants-1985_07
Patent number
US04531002

Reaction notes

Loading…