Methylamine → HCID 20273406, compound

HRID 371507Notes

Reaction equation

HRID 371507 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)=[O:4].[CH3:22][NH2:23]>C(O)C>[ClH:1].[CH3:22][NH:23][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)=[O:4]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 2268912-Chloro-N-{4-[(4-nitrophenyl)sulfanyl]phenyl}acetamide

Product 1

HCID 20273406HCID 20273406, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.0 g of 2-chloro-4'-(p-nitrophenylthio)acetanilide and a 4.0% aqueous solution of methylamine in ethanol was refluxed for 4 hours. The solvent was evaporated, the residue dissolved on dichloromethane and crystallized by the addition of hexane, giving 2.25 g of the desired product, mp 86°-89° C.

Workup

  1. customThe solvent was evaporated
  2. dissolutionthe residue dissolved on dichloromethane
  3. customcrystallized by the addition of hexane

Sources & evidence

ORD record
ord-36d51003b7674819b4c594c22681e699
Source dataset
uspto-grants-1985_07
Patent number
US04532349

Reaction notes

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