反应详情

A mixture of 4.83 g. 3-ethylsulphonyl-1,2,4-triazole, 6.0 g. N-n-pentyl-N-propylcarbamoyl chloride, 40 ml. dry tetrahydrofuran and 6 ml. dry triethylamine was refluxed under anhydrous conditions for 24 hours. The cooled reaction mixture was filtered. The filtrate was distilled under reduced pressure to give 1-(N-n-pentyl-N-propylcarbamoyl)-3-ethylsulphonyl-1,2,4-triazole as a residual oil, nD25 1.4967. (96.5% 1-isomer by GLC assay). Elemental analysis satisfactory.

1. additionA mixture of 4.83 g
2. customThe cooled reaction mixture
3. filtrationwas filtered
4. distillationThe filtrate was distilled under reduced pressure