Water → HCID 20355331, compound

HRID 371646Notes

Reaction equation

HRID 371646 reaction equation
[CH3:1][S:2]([C:5]1[CH:20]=[CH:19][C:8]2[N:9]=[C:10](SC)[C:11]3[C:12](=[CH:14][S:15][CH:16]=3)[NH:13][C:7]=2[CH:6]=1)(=[O:4])=[O:3].O.[NH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>C(O)(=O)C>[CH3:1][S:2]([C:5]1[CH:20]=[CH:19][C:8]2[N:9]=[C:10]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[C:11]3[C:12](=[CH:14][S:15][CH:16]=3)[NH:13][C:7]=2[CH:6]=1)(=[O:3])=[O:4]

Participants

5

Reactant 3

HCID 962WaterHCID 4837PiperazineHCID 20355345HCID 20355345, compound

Product 1

HCID 20355331HCID 20355331, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 6-methylsulfonyl-10-(methylthio)-4H-thieno[3,4-b][1,5]benzodiazepine in excess piperazine and glacial acetic acid is heated in a bomb at 150° C. for 2 days. The solution is poured into water and the product is collected.

Workup

  1. customthe product is collected

Sources & evidence

ORD record
ord-d76a83fadcf14ba08d19296bcb25fff7
Source dataset
uspto-grants-1978_05
Patent number
US04087421

Reaction notes

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