反应详情

10 g. of the 1-aminomethyl-1-cyclohexane-acetic acid, prepared according to Example 1, are dissolved in 50 ml. anhydrous ethanol and saturated at 0° C. with gaseous hydrogen chloride. The reaction mixture is left to stand overnight at ambient temperature, then evaporated in a vacuum and the residue recrystallised from ethanol/ether. Ethyl 1-aminomethyl-1-cyclohexane-acetate is obtained in the form of its hydrochloride; m.p. 161° - 163° C.

1. dissolutionare dissolved in 50 ml
2. customsaturated at 0° C.
3. waitThe reaction mixture is left
4. customevaporated in a vacuum
5. customthe residue recrystallised from ethanol/ether