Hydrochloric Acid → Methyl 2-[1-(aminomethyl)cyclohexyl]acetate

HRID 371726Notes

Reaction equation

HRID 371726 reaction equation
Cl.[NH2:2][CH2:3][C:4]1([CH2:10][C:11]([OH:13])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.Cl.[CH3:15]O>>[NH2:2][CH2:3][C:4]1([CH2:10][C:11]([O:13][CH3:15])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6453919Gabapentin hydrochloride

Product 1

HCID 21692047Methyl 2-[1-(aminomethyl)cyclohexyl]acetate

Procedure

In an analogous manner as described in Example 2, 1-aminomethyl-1-cyclohexane-acetic acid hydrochloride is reacted with methanol in the presence of hydrogen chloride. After evaporation in a vacuum the residue is recrystallised from methanol/ether to give pure methyl 1-aminomethyl-1-cyclohexane-acetate; m.p. 150° - 152° C. (hydrochloride)

Workup

  1. customAfter evaporation in a vacuum the residue
  2. customis recrystallised from methanol/ether

Sources & evidence

ORD record
ord-6ddeb127eacb491e885913265c3b6ddb
Source dataset
uspto-grants-1978_05
Patent number
US04087544

Reaction notes

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