Hydrochloric Acid → Hydrochloric Acid

HRID 371728Notes

Reaction equation

[ClH:1].[NH2:2][CH2:3][C:4]1([CH2:11][C:12]([OH:14])=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.Cl.[CH3:16]O>>[NH2:2][CH2:3][C:4]1([CH2:11][C:12]([O:14][CH3:16])=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.[ClH:1]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 2132113260142-97-4

Product 2

HCID 313Hydrochloric Acid

HCID 22065262HCID 22065262, compound

Procedure

In an anologous manner as described in Example 2 1-aminomethyl-1-cycloheptane acetic acid hydrochloride is esterified with methanol in the presence of hydrogen chloride. After working up and crystallisation from isopropanol/ether/hexane, methyl 1-aminomethyl-1-cycloheptane-acetate is obtained as hydrochloride in the form of colourless crystals having a melting point of 115° - 116° C.

Workup

customcrystallisation from isopropanol/ether/hexane

Sources & evidence

ORD record: ord-8ec7721793964462b92a3bf03a970a0e
Source dataset: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04087544

Reaction notes

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