Hydrochloric Acid → HCID 20356147, compound

HRID 371743Notes

Reaction equation

HRID 371743 reaction equation
[C:1]1([C:6]([C:8]2[N:12]3[CH2:13][CH2:14][CH:15]([C:16]([OH:18])=[O:17])[C:11]3=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.Cl>C(O)CC(C)C>[C:1]1([C:6]([C:8]2[N:12]3[CH2:13][CH2:14][CH:15]([C:16]([O:18][CH2:13][CH2:14][CH:15]([CH3:16])[CH3:11])=[O:17])[C:11]3=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20356074HCID 20356074, compound

Product 1

HCID 20356147HCID 20356147, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A solution of 300 mg. of 5-(2-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml. of isoamyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuum and the residue purified by chromatography on alumina to yield isoamyl 5-(2-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate.

Workup

  1. distillationthe excess alcohol is distilled off in vacuum
  2. customthe residue purified by chromatography on alumina

Sources & evidence

ORD record
ord-8e6658a6bafb4b1d9bfe6603f36821ce
Source dataset
uspto-grants-1978_05
Patent number
US04087539

Reaction notes

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