反应详情

温度

50 °C

Nα -Benzyloxycarbonyl-D-alanyl-L-leucine, methyl ester is prepared by the following procedure. A solution of 8.92 g. of Nα -benzyloxycarbonyl-D-alanine, 7.28 g. of leucine methyl ester hydrochloride and 5.4 g. of 1-hydroxybenztriazole in 120 ml. of dimethylformamide is cooled to -10° C. with stirring and is treated with 5.6 ml. of triethylamine. The mixture is stirred for ten minutes at -10° C. and is treated with 8.6 g. of dicyclohexylcarbodiimide. The reaction is then stirred at -10° C. for fifteen minutes, brought to 0° C. and stirred to 10° during two hours following which it is stirred overnight at 20° C. The mixture is warmed to 50° C. and stirred for 2 hours.

1. additionis treated with 5.6 ml
2. stirringThe mixture is stirred for ten minutes at -10° C.
3. additionis treated with 8.6 g
4. stirringThe reaction is then stirred at -10° C. for fifteen minutes
5. custombrought to 0° C.
6. stirringstirred to 10° during two hours
7. stirringis stirred overnight at 20° C
8. stirringstirred for 2 hours