Diethylamine → 2-Amino-N,N-diethyl-5-methoxy-benzylamine

HRID 371873Notes

Reaction equation

HRID 371873 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4]O.S(Cl)(Cl)=O.[CH2:16]([NH:18][CH2:19][CH3:20])[CH3:17]>C(Cl)Cl>[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4][N:18]([CH2:19][CH3:20])[CH2:16][CH3:17]

Participants

5

Reactant 3

HCID 8021DiethylamineHCID 24386Thionyl ChlorideHCID 13756678(2-Amino-5-methoxyphenyl)methanol

Product 1

HCID 4220092-Amino-N,N-diethyl-5-methoxy-benzylamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Amino-N,N-diethyl-5-methoxy-benzylamine was prepared from 2-amino-5-methoxy-benzyl alcohol, thionyl chloride and diethylamine analogous to Example 1. Proof of structure by IR-, UV- and NMR-spectra. IR-spectrum (methylenechloride): 3260 cm-1NH2 ; 3410 cm-1NH2 ; 2830 cm-1OCH3 ; 2800 cm-1N-ethyl; 1510 cm-1C=C; 1600 cm-1C=C. EXAMPLE 123

Sources & evidence

ORD record
ord-4e450f9dd0c142fc9dfdf355e53e373e
Source dataset
uspto-grants-1978_05
Patent number
USRE029628

Reaction notes

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