Methane → HCID 20351855, compound

HRID 371887Notes

Reaction equation

HRID 371887 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][C:3]=1[CH2:4][N:5](CC1C=CC=CC=1)[CH2:6][CH3:7].[H][H].C.[ClH:27]>CO>[ClH:27].[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7]

Participants

6

Reactant 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 20351866HCID 20351866, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20351855HCID 20351855, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.8 gm of 2-amino-N-benzyl-5-carbethoxy-N-ethyl-benzylamine were hydrogenated in a mixture of 50 ml of methanol and 1 ml of concentrated hydrochloric acid at room temperature and at a hydrogen pressure of 5 atmospheres in the presence of palladized charcoal. Then, the catalyst was filtered off, and the filtrate was evaporated to dryness in vacuo. The residue was recrystallized from ethanol by addition of ether, yielding 2-amino-5-carbethoxy-N-ethyl-benzylamine hydrochloride, m.p. 173-176° C (decomp.).

Workup

  1. filtrationThen, the catalyst was filtered off
  2. customthe filtrate was evaporated to dryness in vacuo
  3. customThe residue was recrystallized from ethanol by addition of ether

Sources & evidence

ORD record
ord-094762672efa47318cced6b7866f00a1
Source dataset
uspto-grants-1978_05
Patent number
USRE029628

Reaction notes

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