反应详情

A solution of 22 g of 4-(4-chlorobenzyl)-phenol and 18.5 g of α-bromopropionic acid ethyl ester in 100 ml of dimethyl formamide was stirred for 2 hours at 100° C together with 16 g of potassium carbonate. After cooling, the reaction mixture was poured into 1 liter of water. An oil precipitated which was separated and dried over sodium sulfate. By means of vacuum distillation, 23.3 g of 2-[p-(4-chlorobenzyl)-phenoxi]-propionic acid ethyl ester were obtained. b.p.: 146° - 151° C/0.1 mm Hg/nD22 : 1.5527 ##STR4##

1. temperatureAfter cooling
2. customAn oil precipitated which
3. customwas separated
4. dry with materialdried over sodium sulfate
5. distillationBy means of vacuum distillation