HRID37194

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID187201

N-Boc-ethylenediamine

C7H16N2O2

结构：COC(=O)c1cnc(NCCCN2CCN(c3cc(Cl)ccc3OC)CC2)cn1

HCID19934797

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Cl)cc1N1CCN(CCCNc2cnc(C(=O)NCCNC(=O)OC(C)(C)C)cn2)CC1

HCID19934801

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

4 g (0.0095 mol) of methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperain-1-yl]propyl]amino]-pyrazine-5-carboxylate and 3.05 g (0.02 mol) of 1,1-dimethylethyl 2-aminoethylcarbamate are introduced into 10 ml of 2-propanol in a 0.5 l round-bottomed flask and the mixture is heated at reflux for 2 days.

WORKUP

后处理

temperaturethe mixture is heated
temperatureat reflux for 2 days

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2aed04866ac14fcbad5c553531ab1af8
来源数据集: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05420130
来源说明: uspto-grants-1995_05

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[CH:23]=[N:22][C:21]([C:24](OC)=[O:25])=[CH:20][N:19]=3)[CH2:10][CH2:9]2)[CH:7]=1.[NH2:30][CH2:31][CH2:32][NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37]>CC(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[CH:23]=[N:22][C:21]([C:24]([NH:30][CH2:31][CH2:32][NH:33][C:34](=[O:40])[O:35][C:36]([CH3:37])([CH3:39])[CH3:38])=[O:25])=[CH:20][N:19]=3)[CH2:12][CH2:13]2)[CH:7]=1