N-BOC-ethylenediamine → HCID 19934801, compound

HRID 37194Notes

Reaction equation

HRID 37194 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[CH:23]=[N:22][C:21]([C:24](OC)=[O:25])=[CH:20][N:19]=3)[CH2:10][CH2:9]2)[CH:7]=1.[NH2:30][CH2:31][CH2:32][NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37]>CC(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[CH:23]=[N:22][C:21]([C:24]([NH:30][CH2:31][CH2:32][NH:33][C:34](=[O:40])[O:35][C:36]([CH3:37])([CH3:39])[CH3:38])=[O:25])=[CH:20][N:19]=3)[CH2:12][CH2:13]2)[CH:7]=1

Participants

4

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 19934797HCID 19934797, compound

Product 1

HCID 19934801HCID 19934801, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4 g (0.0095 mol) of methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperain-1-yl]propyl]amino]-pyrazine-5-carboxylate and 3.05 g (0.02 mol) of 1,1-dimethylethyl 2-aminoethylcarbamate are introduced into 10 ml of 2-propanol in a 0.5 l round-bottomed flask and the mixture is heated at reflux for 2 days.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 2 days

Sources & evidence

ORD record
ord-2aed04866ac14fcbad5c553531ab1af8
Source dataset
uspto-grants-1995_05
Patent number
US05420130

Reaction notes

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