HCID 178449602, compound → HCID 178479356, compound

HRID 372080Notes

Reaction equation

HRID 372080 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13]([NH:15]C(C)(C)C)=[O:14])=[NH:11]>Cl>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13]([NH2:15])=[O:14])=[NH:11]

Participants

3

Reactant 1

HCID 178449602HCID 178449602, compound

Product 1

HCID 178479356HCID 178479356, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 32.1 g. (0.106 moles) of 1-(2,6-dichlorophenylamidino)-3-(t-butyl)urea and 200 ml of conc. hydrochloric acid is refluxed for 1/2 hour. The reaction mixture is cooled, filtered and washed with 10 ml of 1:1 HCl/H2O and dried. The product is then recrystallized from ethanol-ether to obtain (2,6-dichlorophenylamidino)urea hydrochloride.

Workup

  1. additionA mixture of 32.1 g
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. washwashed with 10 ml of 1:1 HCl/H2O
  5. customdried
  6. customThe product is then recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-38999293618c4c159ce124ffe5460606
Source dataset
uspto-grants-1978_05
Patent number
US04088785

Reaction notes

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