Hydrochloric Acid → HCID 20528114, compound

HRID 372230Notes

Reaction equation

HRID 372230 reaction equation
[C:1]1([CH3:20])[CH:6]=[CH:5][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([OH:19])=[O:18])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:3][CH:2]=1.Cl>C(O)CC(C)C>[C:1]1([CH3:20])[CH:2]=[CH:3][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([O:19][CH2:3][CH2:2][CH:1]([CH3:20])[CH3:6])=[O:18])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13487034HCID 13487034, compound

Product 1

HCID 20528114HCID 20528114, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A solution of 300 mg. of 5-p-toluoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml. of isoamyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue purified by chromatography on alumina, to yield isoamyl 5-p-toluoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate.

Workup

  1. distillationthe excess alcohol is distilled off in vacuo
  2. customthe residue purified by chromatography on alumina

Sources & evidence

ORD record
ord-ca7bf19ba4534436b31d6e634d083289
Source dataset
uspto-grants-1978_05
Patent number
US04089969

Reaction notes

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