Methylamine → HCID 53963722, compound

HRID 372547Notes

Reaction equation

HRID 372547 reaction equation
[CH3:1][NH2:2].[O:3]=[C:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[CH2:8][CH2:7][CH:6]=[CH:5]1>C1C=CC=CC=1.C(O)C>[CH3:1][NH:2][CH:6]1[CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:4](=[O:3])[CH2:5]1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 9989489HCID 9989489, compound

Product 1

HCID 53963722HCID 53963722, compoundYield 99.3%

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 702EthanolSolvent

Procedure

A solution of 22.7 g of monomethylamine in 160 ml of benzene was added to a solution of 40 g of 5-oxo-8,9-dihydro [5H] benzocycloheptene in 400 ml of ethanol and the mixture was stirred for 2 1/2 hours and was evaporated to dryness to obtain 47.5 g of 7-methylamino-5-oxo-6,7,8,9-tetrahydro [5H] benzocycloheptene which was used as is for the next step.

Workup

  1. customwas evaporated to dryness

Sources & evidence

ORD record
ord-8f1b9237e1e2402aab465292866b6386
Source dataset
uspto-grants-1978_05
Patent number
US04091115

Reaction notes

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