Water → HCID 178513771, compound

HRID 372635Notes

Reaction equation

HRID 372635 reaction equation
[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].[NH2:10][C:11](N)=[O:12].O>CN1CCCC1=O>[OH:3][C:2]1[N:4]=[C:5]([OH:6])[C:7]([C:11]([NH2:10])=[O:12])=[C:8]([OH:9])[N:1]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1176UreaHCID 6211Barbituric Acid

Product 1

HCID 178513771HCID 178513771, compoundYield 96.5%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A mixture of 128 grams of barbituric acid and 120 grams of urea in 200 ml of 1-methyl-2-pyrrolidone was heated at 145° for 15 minutes. Hot water was then added to the reaction mixture; a white solid precipitated and was collected by filtration. The precipitate was washed with hot dimethylformamide and dried to give 165 grams of 2,4,6-trihydroxy-5-pyrimidinecarboxamide; mp, >270°. The mass spectrum of the product was consistent with the assigned structure.

Workup

  1. temperaturewas heated at 145° for 15 minutes
  2. customa white solid precipitated
  3. filtrationwas collected by filtration
  4. washThe precipitate was washed with hot dimethylformamide
  5. customdried

Sources & evidence

ORD record
ord-8c99f0f9908e4206b4884b0e702a6df1
Source dataset
uspto-grants-1978_05
Patent number
US04092150

Reaction notes

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