Hydrazine hydrate (1:1) → 3-(4-Chlorophenyl)-6-hydrazinylpyridazine

HRID 372698Notes

Reaction equation

HRID 372698 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11](Cl)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([NH:16][NH2:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 122575023-Chloro-6-(4-chlorophenyl)pyridazine

Product 1

HCID 127268633-(4-Chlorophenyl)-6-hydrazinylpyridazine

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 10.0 g. of 6-(p-chlorophenyl)-3-chloropyridazine, 6.6 g. of hydrazine hydrate and 150 ml. of butanol is heated at reflux overnight. The reaction mixture is cooled and the precipitate is collected by filtration, washed with butanol and water and then dried yielding 6-(p-chlorophenyl)-3-hydrazinopyridazine.

Workup

  1. additionA mixture of 10.0 g
  2. temperatureat reflux overnight
  3. temperatureThe reaction mixture is cooled
  4. filtrationthe precipitate is collected by filtration
  5. washwashed with butanol and water
  6. customdried

Sources & evidence

ORD record
ord-b0b02fcee0a44c98a5d896154f42a7c5
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

Loading…