反应详情

In 50 ml of dry THF, were suspended 3.0 g of oa (6-methoxy-2-naphthyl)-propanamide, followed by adding thereto 8.3 g of trifluoroacetic anhydride and then stirring at room temperature for 12 hours. The resulting reaction mixture was poured into 200 ml of iced water, and then precipitated white solid was filtered off. After purifying with silica gel column, the product was recrystallized twice with ethanol to obtain 2.1 g of oa (6-methoxy-2-naphthyl)propanonitrile (Compound No. 1-1) of this invention.

1. additionby adding
2. customThe resulting reaction mixture
3. customprecipitated white solid
4. filtrationwas filtered off
5. customAfter purifying with silica gel column
6. customthe product was recrystallized twice with ethanol