反应详情

Following the procedure of Example 5, a mixture of 5-(4-chlorobutyl)-3-(1-methylethyl)-2-oxazolidinone (5.2 g, 0.0237 mol), 1-(2-methoxyphenyl)piperazine (4.56 g, 0.0237 mol), potassium carbonate (9.84 g, 0.0712 mol) and potassium iodide (1.0 g) in n-butanol (200 mL) gave an oil. The oil was dissolved in absolute ethanol and acidified with ethanolic hydrogen chloride. Addition of ether gave a solid which was collected by filtration and dried under high vacuum at 70° C. to give 7.36 g (69% yield), mp 206°-213° C.

1. customgave an oil
2. customgave a solid which
3. filtrationwas collected by filtration
4. customdried under high vacuum at 70° C.
5. customto give 7.36 g (69% yield), mp 206°-213° C.