Dichloromethane → HCID 88506377, compound

HRID 373106Notes

Reaction equation

HRID 373106 reaction equation
C(N(CC)CC)C.[Cl:8][C:9]1[CH:10]=[C:11]([N:32]=[C:33]=[O:34])[CH:12]=[C:13]([Cl:31])[C:14]=1[O:15][C:16]([F:30])([F:29])[CH:17]([O:19][C:20]([F:28])([F:27])[C:21]([F:26])([F:25])[CH:22]([F:24])[F:23])[F:18].[CH3:35][N:36]1[C:43](=[O:44])[CH2:42][C:40](=[O:41])[N:39]([CH3:45])[C:37]1=[O:38].C(Cl)Cl>C1(C)C=CC=CC=1>[CH3:45][N:39]1[C:40](=[O:41])[CH:42]([C:33](=[O:34])[NH:32][C:11]2[CH:10]=[C:9]([Cl:8])[C:14]([O:15][C:16]([F:29])([F:30])[CH:17]([O:19][C:20]([F:28])([F:27])[C:21]([F:25])([F:26])[CH:22]([F:23])[F:24])[F:18])=[C:13]([Cl:31])[CH:12]=2)[C:43](=[O:44])[N:36]([CH3:35])[C:37]1=[O:38]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 69860Dimethylbarbituric acidHCID 14819450HCID 14819450, compound

Product 1

HCID 88506377HCID 88506377, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
40 °C

Procedure

1.04 g (10.3 mmol) of triethylamine and then 9.25 g (20.5 mmol) of 3,5-dichloro-(4-(2-(1,1,2,2,3,3-hexafluoropropoxy)-1,1,2-trifluoroethoxy))-phenyl isocyanate were added to 3.20 g (20.5 mmol) of 1,3-dimethylbarbituric acid in 40 ml of toluene at room temperature. The mixture was subsequently stirred at 40° C. for 2 hours, 200 ml of methylene chloride were added and the mixture was washed with 100 ml of 2N aqueous hydrochloric acid and several times with water. After drying over magnesium sulfate, the mixture was concentrated.

Workup

  1. washthe mixture was washed with 100 ml of 2N aqueous hydrochloric acid and several times with water
  2. dry with materialAfter drying over magnesium sulfate
  3. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-4887cc27beeb403486d4c78e08a1040c
Source dataset
uspto-grants-1992_11
Patent number
US05162327

Reaction notes

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