Pyridine → 1,8-Diazabicyclo(5.4.0)undec-7-ene

HRID 373131Notes

Reaction equation

HRID 373131 reaction equation
ClC([O-])=O.[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C1COCC1>[CH2:8]1[CH2:9][CH2:10][N:5]2[C:10](=[N:5][CH2:6][CH2:7][CH2:8]2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 1049PyridineHCID 21226386Carbonochloridate

Product 1

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compounds of Formula (I) wherein R1 is -SO2NHCO2R22 may be prepared by reacting an appropriate chloroformate with the sulfonamide (39) in pyridine or in the presence of DBU in THF to afford the desired compound (41), as outlined in Scheme 12. ##STR54##

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-c88ba714e60542d085d92521a1f02978
Source dataset
uspto-grants-1992_11
Patent number
US05162340

Reaction notes

Loading…