1-Phenylpiperazine → 1-[Bis(2,2-dimethylpropoxy)methyl]-4-phenylpiperazine

HRID 373320Notes

Reaction equation

HRID 373320 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:13]([O:18][CH:19]([O:23][CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])N(C)C)[C:14]([CH3:17])([CH3:16])[CH3:15]>C(Cl)(Cl)Cl>[CH3:15][C:14]([CH3:17])([CH3:16])[CH2:13][O:18][CH:19]([O:23][CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])[N:10]1[CH2:11][CH2:12][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 786231,1-Bis(2,2-dimethylpropoxy)-N,N-dimethylmethanamine

Product 1

HCID 198123021-[Bis(2,2-dimethylpropoxy)methyl]-4-phenylpiperazine

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 4-phenylpiperazine (0.162 g, 0.001 mol) and dimethylformamide dineopentyl acetal (0.346 g, 0.0015 mol) in anhydrous chloroform (5 mL) was refluxed for 10 hours. The solvent and excess reagent were removed (100° C./1 mm) to give the product in quantitative yield.

Workup

  1. customThe solvent and excess reagent were removed (100° C./1 mm)
  2. customto give the product in quantitative yield

Sources & evidence

ORD record
ord-13225cc0a0264e19bac3a7fc77ca1668
Source dataset
uspto-grants-1992_11
Patent number
US05162523

Reaction notes

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