Ethanol → 1-(4-Methoxyethoxymethoxyphenyl)-2-hydroxy-1-propanone

HRID 373462Notes

Reaction equation

HRID 373462 reaction equation
CC1C=CC(S([O-])(=O)=[O:9])=CC=1.[CH:12]1[CH:17]=C[NH+]=CC=1.[CH2:18]([OH:20])C.C(C1C=CC(C2C=CC(C([O:42][CH:43]([CH3:56])[C:44]([C:46]3[CH:51]=[CH:50][C:49]([O:52][CH2:53]C=C)=[CH:48][CH:47]=3)=[O:45])=O)=CC=2)=CC=1)CCCCCC>O>[CH3:18][O:20][CH2:17][CH2:12][O:9][CH2:53][O:52][C:49]1[CH:48]=[CH:47][C:46]([C:44](=[O:45])[CH:43]([OH:42])[CH3:56])=[CH:51][CH:50]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 198100571-Methyl-2-(4'-allyloxy-phenyl)-2-keto-ethyl 4'-heptylbiphenyl-4-ylcarboxylate

Product 1

HCID 572635601-(4-Methoxyethoxymethoxyphenyl)-2-hydroxy-1-propanone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To this compound, 0.5 g of PPTS and 100 ml of ethanol were added, and the resulting mixture was stirred at room temperature. After addition of water, the mixture was extracted with toluene. The organic layer thus obtained was neutralized, washed with water, dried, and then concentrated to obtain the desired (S) 1-(4-methoxyethoxymethoxyphenyl)-2-hydroxy-1-propane.

Workup

  1. extractionthe mixture was extracted with toluene
  2. customThe organic layer thus obtained
  3. washwashed with water
  4. customdried
  5. concentrationconcentrated
  6. customto obtain the

Sources & evidence

ORD record
ord-1573c6f6679b442a8460970fa997c9e7
Source dataset
uspto-grants-1992_11
Patent number
US05164112

Reaction notes

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