Water → HCID 19810492, compound

HRID 373479Notes

Reaction equation

HRID 373479 reaction equation
[NH:1]1[CH2:4][CH2:3][CH2:2]1.[CH2:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]1=O.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>ClCCl>[CH:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][CH2:6][C:7]=1[N:1]1[CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 10422AzetidineHCID 682662-Tetralone

Product 1

HCID 19810492HCID 19810492, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of azetidine (6.8 g, 0.12 mol), 3,4-dihydro-2(1 H)-naphthalenone (14.6 g, 0.10 mol), and p-toluenesulphonic acid (1.5 g) in dichloromethane (200 ml) was heated under reflux for 3 h in an apparatus fitted for the continuous removal of water, cooled to room temperature, washed with dilute aqueous sodium carbonate, dried (MgSO4), and evaporated in vacuo to give the product as an oil.

Workup

  1. temperatureunder reflux for 3 h in an apparatus
  2. washwashed with dilute aqueous sodium carbonate
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-56ee45376a3a4bb58b9e5d3949ab4e29
Source dataset
uspto-grants-1992_11
Patent number
US05164385

Reaction notes

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