Sodium → HCID 86746334, compound

HRID 373533Notes

Reaction equation

HRID 373533 reaction equation
[Na:1].[C:2]1([N:8]2[C:15](=[O:16])[CH:14]([C:17](=[O:19])[CH3:18])[C:12](=[O:13])[N:11]([CH2:20][C:21]#[CH:22])[C:9]2=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[C:2]1([N:8]2[C:15](=[O:16])[CH:14]([C:17](=[O:19])[CH3:18])[C:12](=[O:13])[N:11]([CH2:20][C:21]#[CH:22])[C:9]2=[O:10])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na:1]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 198106385-Acetyl-1-phenyl-3-(prop-2-yn-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione

Product 1

HCID 86746334HCID 86746334, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of 0.23 g of sodium in 25 ml of methanol is added to a suspension of 2.84 g of 1-phenyl-3-propargyl-5-acetyl barbituric acid prepared as described in Example I, in ml of methanol. The reaction mixture is left to stand overnight while stirring, after which the methanol is evaporated. The residue is stirred with diethyl ether, sucked off and dried. The title compound (8) is obtained in a yield of 2.62 g; melting-point >260° C.

Workup

  1. customprepared
  2. waitThe reaction mixture is left
  3. customafter which the methanol is evaporated
  4. stirringThe residue is stirred with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-27b005abe9ff4de7a05f0f2e08710203
Source dataset
uspto-grants-1992_11
Patent number
US05164396

Reaction notes

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