反应详情

A solution of 0.23 g of sodium in 25 ml of methanol is added to a suspension of 2.84 g of 1-phenyl-3-propargyl-5-acetyl barbituric acid prepared as described in Example I, in ml of methanol. The reaction mixture is left to stand overnight while stirring, after which the methanol is evaporated. The residue is stirred with diethyl ether, sucked off and dried. The title compound (8) is obtained in a yield of 2.62 g; melting-point >260° C.

1. customprepared
2. waitThe reaction mixture is left
3. customafter which the methanol is evaporated
4. stirringThe residue is stirred with diethyl ether
5. customdried