Phenylhydrazine → HCID 86746349, compound

HRID 373829Notes

Reaction equation

HRID 373829 reaction equation
[C:1]1([NH:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][C:11]=1[C:16](=O)[CH3:17]>>[C:1]1([NH:7][N:8]=[C:16]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][C:10]=2[NH2:9])[CH3:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7516Phenylhydrazine2×HCID 107730271-(4-Amino-3-pyridinyl)ethanone2×

Product 1

HCID 86746349HCID 86746349, compound

Conditions

Temperature
100 °C

Procedure

Phenylhydrazine (4.0 ml) was added to 5.00 g 1-(4-amino-3-pyridinyl)ethanone, and the mixture was stirred at 100° C. for seventeen hours. A similar procedure was followed using 4.0 g 1-(4-amino-3-pyridinyl)ethanone and 3.20 ml phenylhydrazine. The products of the two reactions were combined and purified by flash chromatography to yield 9.74 g solid. Recrystallization of 1.24 g from CH3OH/water yielded 0.28 g solid, m.p. 168°-170° C.

Workup

  1. custompurified by flash chromatography

Sources & evidence

ORD record
ord-79ba4b5c1ead43e1b90eccf3031cce4c
Source dataset
uspto-grants-1992_11
Patent number
US05166170

Reaction notes

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