Phenacylamine → 2-Aminoacetophenone 3-chlorophenylhydrazone

HRID 373830Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 373830
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl:11][C:12]1[CH:13]=[C:14]([NH:18][NH2:19])[CH:15]=[CH:16][CH:17]=1>CC(O)=O.CCO.O>[Cl:11][C:12]1[CH:13]=[C:14]([NH:18][N:19]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:2][NH2:1])[CH:15]=[CH:16][CH:17]=1

Komponenten

6

Edukt 2

HCID 11952PhenacylamineHCID 75332(3-Chlorophenyl)hydrazine

Produkt 1

HCID 867463502-Aminoacetophenone 3-chlorophenylhydrazoneAusbeute 86,1 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 3.12 g 2-aminoacetophenone and 3.29 g 3-chlorophenylhydrazine in 4 ml HOAc and 20 ml EtOH was refluxed for one hour. The cooled reaction mixture was diluted with water and the precipitate was collected, washed with water, and dried to give 5.16 g solid. Recrystallization from methanol gave 2.12 g solid, m.p. 131°-134° C.

Aufarbeitung

  1. temperaturewas refluxed for one hour
  2. customThe cooled reaction mixture
  3. customthe precipitate was collected
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1cff82c141024b30aeea05eb600793b9
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05166170

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