Hydrochloric Acid → 3-oxoheptanenitrile

Temperature

-78 °C

To a mechanically stirred solution of 14.3 g MgSO4 -dried cyanoacetic acid and ~100 mg 1,10-phenanthroline in 500 mL THF at -78° C. was added 60 mL 2.5M n-butyllithium in hexanes (~one half of the total). The indicator color persisted at this point. The solution was warmed to -5° to +5° C. after which the indicator color disappeared. Another 55 mL 2.5M n-butyllithium in hexanes was added until the indicator color again persisted. The mixture was cooled to -78° C. then 10.0 mL valeroyl chloride in 10 mL THF was added over 3 minutes. After 10 minutes the now yellow solution was allowed to warm to room temperature and stir for 1 hour. The mixture was poured into a solution of 50 mL concentrated HCl in 300 mL water. The mixture was extracted 3 times with ether. The combined organic material was washed twice with saturated NaHCO3 solution then once with brine. The washes were back extracted with ether and the back extracts were washed with brine. The back extracts were combined with the other organic material and then were dried over MgSO4. The organic material was stripped of solvent in vacuo then was distilled at ~1 Torr with the title compound distilling at 87°-91° C. The title compound was isolated as a clear oil, 6.32 g, 60% yield. To this material there was added 1% by weight BHT to prevent polymerization. The material was also kept refrigerated at 0° C. under nitrogen. Rf 0.18 in 20% EtOAc/hexane, visualized by ninhydrin stain; 1H-NMR (300 MHz, CDCl3): δ3.46 (s, 2H), 2.62 (3 line m, 2H), 1.61 (m, 2H), 1.35 (m, 2H), 0.92 (t, J=7.3 Hz, 3H); 13C-NMR (75.4 MHz, CDCl3): δ197.6, 113.8, 41.9, 31.9, 25.3, 22.0, 13.7.

1. temperatureThe solution was warmed to -5° to +5° C. after which the indicator color
2. temperatureto warm to room temperature
3. extractionThe mixture was extracted 3 times with ether
4. washThe combined organic material was washed twice with saturated NaHCO3 solution
5. extractionThe washes were back extracted with ether
6. washthe back extracts were washed with brine
7. dry with materialwere dried over MgSO4
8. distillationthen was distilled at ~1 Torr with the title compound
9. distillationdistilling at 87°-91° C

ORD record

ord-08eed338a4f84b89962e05469e363dc8

Source dataset

uspto-grants-1992_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05166206