反应详情

A mixture of acetate of 6-acetylamino-1-methylhexahydro-1H-1,4-diazepine (3.0 g), 3-methylbenzyl chloride (3.5 g), potassium carbonate (17 g), sodium iodide (0.1 g) and methyl ethyl ketone (200 ml) is refluxed with stirring for 16 hours. The reaction mixture is filtered, and the filtrate is concentrated under reduced pressure. The residue is chromatographed on silica gel with elution of chloroform-methanol (20:1). Fractions containing the title compound are pooled and evaporated under reduced pressure to give the title compound as an oil.

1. temperatureis refluxed
2. filtrationThe reaction mixture is filtered
3. concentrationthe filtrate is concentrated under reduced pressure
4. customThe residue is chromatographed on silica gel with elution of chloroform-methanol (20:1)
5. additionFractions containing the title compound
6. customevaporated under reduced pressure